Prophylactic effect of L 5 hydroxytryptophan on self mutilation in the Lesch Nyhan syndrome

Prophylactic effect of L 5 hydroxytryptophan on self mutilation in the Lesch Nyhan syndrome

Mizuno T; Yugari Y

Neuropadiatrie

1975

behavioral problems; tone and motor problems; Lesch-Nyhan syndrome; pharmacologic intervention; L-5-Hydroxytryptophan; L-tryptophan; L-Dopa; self-injury; choreoathetosis

Four cases of the Lesch Nyhan syndrome found in the Tokyo area were given L 5 hydroxytryptophan orally. L 5 hydroxy tryptophan relieved self mutilation effectively without causing any side effects. However this substance did not alleviate choreoathetoid movement. Self destructive behavior may be caused by an imbalance of cerebral amines, especially of serotonin.

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).