Prophylactic effect of L 5 hydroxytryptophan on self mutilation in the Lesch Nyhan syndrome
Title
Prophylactic effect of L 5 hydroxytryptophan on self mutilation in the Lesch Nyhan syndrome
Creator
Mizuno T; Yugari Y
Identifier
Publisher
Neuropadiatrie
Date
1975
Subject
behavioral problems; tone and motor problems; Lesch-Nyhan syndrome; pharmacologic intervention; L-5-Hydroxytryptophan; L-tryptophan; L-Dopa; self-injury; choreoathetosis
Description
Four cases of the Lesch Nyhan syndrome found in the Tokyo area were given L 5 hydroxytryptophan orally. L 5 hydroxy tryptophan relieved self mutilation effectively without causing any side effects. However this substance did not alleviate choreoathetoid movement. Self destructive behavior may be caused by an imbalance of cerebral amines, especially of serotonin.
Rights
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URL Address
Citation
Mizuno T; Yugari Y, “Prophylactic effect of L 5 hydroxytryptophan on self mutilation in the Lesch Nyhan syndrome,” Pediatric Palliative Care Library, accessed February 10, 2025, https://pedpalascnetlibrary.omeka.net/items/show/16746.