Prophylactic effect of L 5 hydroxytryptophan on self mutilation in the Lesch Nyhan syndrome

Title

Prophylactic effect of L 5 hydroxytryptophan on self mutilation in the Lesch Nyhan syndrome

Creator

Mizuno T; Yugari Y

Publisher

Neuropadiatrie

Date

1975

Subject

behavioral problems; tone and motor problems; Lesch-Nyhan syndrome; pharmacologic intervention; L-5-Hydroxytryptophan; L-tryptophan; L-Dopa; self-injury; choreoathetosis

Description

Four cases of the Lesch Nyhan syndrome found in the Tokyo area were given L 5 hydroxytryptophan orally. L 5 hydroxy tryptophan relieved self mutilation effectively without causing any side effects. However this substance did not alleviate choreoathetoid movement. Self destructive behavior may be caused by an imbalance of cerebral amines, especially of serotonin.

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Citation

Mizuno T; Yugari Y, “Prophylactic effect of L 5 hydroxytryptophan on self mutilation in the Lesch Nyhan syndrome,” Pediatric Palliative Care Library, accessed September 18, 2021, https://pedpalascnetlibrary.omeka.net/items/show/16746.

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