Sixty-four patients with Brachmann-de Lange syndrome: a survey
Title
Sixty-four patients with Brachmann-de Lange syndrome: a survey
Creator
Hawley P P; Jackson L G; Kurnit D M
Identifier
Publisher
American Journal of Medical Genetics
Date
1985
Subject
Male; Surveys and Questionnaires; Child; Humans; Female; Psychomotor Performance; Birth Weight; De Lange Syndrome/etiology/genetics/physiopathology; behavioral problems; breathing difficulties; feeding difficulties; De Lange syndrome; trajectory; characteristics; respiratory tract symptoms
Description
We surveyed 64 individuals with the diagnosis of Brachmann-de Lange syndrome (BDLS) to determine the natural course and cause of the disorder. The 64 individuals were ascertained through membership in a national organization, the Cornelia de Lange Syndrome (CDLS) Foundation, comprised of families who have a relative with BDLS. We surveyed 64 families by questionnaire and personally examined 24 of the 64. Our data suggest that lower birth weight correlates with a more severe phenotype, specifically including severe upper limb malformations and greater psychomotor retardation. The lower birth weight group showed a significant excess of females. The miscarriage rate was normal and there were no recurrences reported in the 64 families we surveyed. Major management problems included feeding problems and projectile vomiting, behavioral problems including frequent tantrums, hearing and dental difficulties, and recurrent respiratory tract infections. The oldest, teenaged subjects in our study entered puberty; although pregnancy has not been reported in the syndrome, it is likely that people with BDLS are fertile. Though most BDLS children reared at home survive through adolescence, a significant degree of psychomotor retardation and difficult medical management problems still occur.
Rights
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
URL Address
Citation
Hawley P P; Jackson L G; Kurnit D M, “Sixty-four patients with Brachmann-de Lange syndrome: a survey,” Pediatric Palliative Care Library, accessed April 18, 2024, https://pedpalascnetlibrary.omeka.net/items/show/16680.