Pallidal stimulation improves pantothenate kinase-associated neurodegeneration

Title

Pallidal stimulation improves pantothenate kinase-associated neurodegeneration

Creator

Castelnau P; Cif L; Valente E M; Vayssiere N; Hemm S; Gannau A; Digiorgio A; Coubes P

Identifier

Publisher

Annals of Neurology

Date

2005

Subject

tone and motor problems; IND; surgical intervention; Pallidal Stimulation; dystonia

Description

Pantothenate kinase-associated neurodegeneration (PKAN) causes a progressive generalized dystonia which remains pharmacologically intractable. We performed bilateral internal globus pallidus stimulation in six patients with genetically confirmed PKAN who obtained a major and long-lasting improvement of their painful spasms, dystonia, and functional autonomy. This study shows the benefits of pallidal DBS for the dystonia of PKAN patients.

Rights

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Citation

Castelnau P; Cif L; Valente E M; Vayssiere N; Hemm S; Gannau A; Digiorgio A; Coubes P, “Pallidal stimulation improves pantothenate kinase-associated neurodegeneration,” Pediatric Palliative Care Library, accessed May 18, 2024, https://pedpalascnetlibrary.omeka.net/items/show/16608.