A favorable response to antiparkinsonian treatment in juvenile neuronal ceroid lipofuscinosis

Title

A favorable response to antiparkinsonian treatment in juvenile neuronal ceroid lipofuscinosis

Creator

Aberg L E; Rinne J O; Rajantie I; Santavuori P

Publisher

Neurology

Date

2001

Subject

tone and motor problems; NCL3; NCL6; pharmacologic intervention; levodopa; selegiline

Description

To study the effect of dopaminergic drugs on the parkinsonism in juvenile neuronal ceroid lipofuscinosis, the authors conducted an open study of 21 patients. According to the motor Unified PD Rating Scale (UPDRS) score, treatment was initiated with either levodopa (n = 10) or selegiline (n = 6). Five patients served as a control group. The UPDRS score after 1 year was compared with the score at onset. Both in the control group and in the selegiline group, the mean UPDRS score increased, whereas in the levodopa group, the mean UPDRS score decreased. The difference between the levodopa group and the control group was significant.

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Citation

Aberg L E; Rinne J O; Rajantie I; Santavuori P, “A favorable response to antiparkinsonian treatment in juvenile neuronal ceroid lipofuscinosis,” Pediatric Palliative Care Library, accessed September 27, 2021, https://pedpalascnetlibrary.omeka.net/items/show/16562.

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