A favorable response to antiparkinsonian treatment in juvenile neuronal ceroid lipofuscinosis
Title
A favorable response to antiparkinsonian treatment in juvenile neuronal ceroid lipofuscinosis
Creator
Aberg L E; Rinne J O; Rajantie I; Santavuori P
Identifier
Publisher
Neurology
Date
2001
Subject
tone and motor problems; NCL3; NCL6; pharmacologic intervention; levodopa; selegiline
Description
To study the effect of dopaminergic drugs on the parkinsonism in juvenile neuronal ceroid lipofuscinosis, the authors conducted an open study of 21 patients. According to the motor Unified PD Rating Scale (UPDRS) score, treatment was initiated with either levodopa (n = 10) or selegiline (n = 6). Five patients served as a control group. The UPDRS score after 1 year was compared with the score at onset. Both in the control group and in the selegiline group, the mean UPDRS score increased, whereas in the levodopa group, the mean UPDRS score decreased. The difference between the levodopa group and the control group was significant.
Rights
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URL Address
Citation
Aberg L E; Rinne J O; Rajantie I; Santavuori P, “A favorable response to antiparkinsonian treatment in juvenile neuronal ceroid lipofuscinosis,” Pediatric Palliative Care Library, accessed April 25, 2024, https://pedpalascnetlibrary.omeka.net/items/show/16562.