Early neurodevelopmental outcomes of extremely preterm infants


Early neurodevelopmental outcomes of extremely preterm infants


Rogers EE; Hintz SR


Seminars In Perinatology




Biomedical Research; Infant; neonatology; Adhd; Brain/embryology/ physiopathology; cerebral palsy; Developmental Disabilities/etiology/ physiopathology; Diseases/ physiopathology; Extremely Premature/growth & development/physiology/psychology; Fetal Organ Maturity; Humans; infant; intellectual impairment; intraventricular hemorrhage; Nervous System Diseases/etiology/ physiopathology; neurodevelopment; neurodevelopmental outcomes; Newborn; Premature; preterm birth; Risk Factors; sensory impairment; Survival Rate/trends; Very Low Birth Weight/growth & development/physiology/psychology; white matter injury


Infants born at extreme preterm gestation are at risk for both death and disability. Although rates of survival have improved for this population, and some evidence suggests a trend toward decreased neuromotor impairment over the past decades, a significant improvement in overall early neurodevelopmental outcome has not yet been realized. This review will examine the rates and types of neurodevelopmental impairment seen after extremely preterm birth, including neurosensory, motor, cognitive, and behavioral outcomes. We focus on early outcomes in the first 18-36 months of life, as the majority of large neonatal studies examining neurodevelopmental outcomes stop at this age. However, this early age is clearly just a first glimpse into lifetime outcomes; the neurodevelopmental effects of extreme prematurity may last through school age, adolescence, and beyond. Importantly, prematurity appears to be an independent risk factor for adverse development, but this population demonstrates considerable variability in the types and severity of impairments. Understanding both the nature and prevalence of neurodevelopmental impairment among extremely preterm infants is important because it can lead to targeted interventions that in turn may lead to improved outcomes.


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Citation List Month

March 2018 List



Rogers EE; Hintz SR, “Early neurodevelopmental outcomes of extremely preterm infants,” Pediatric Palliative Care Library, accessed September 30, 2023, https://pedpalascnetlibrary.omeka.net/items/show/14606.