Absolute leukocyte telomere length in HIV-infected and uninfected individuals: evidence of accelerated cell senescence in HIV-associated chronic obstructive pulmonary disease

Title

Absolute leukocyte telomere length in HIV-infected and uninfected individuals: evidence of accelerated cell senescence in HIV-associated chronic obstructive pulmonary disease

Creator

Liu JCY; Leung JM; Ngan DA; Nashta NF; Guillemi S; Harris M; Lima VD; Um Soo-Jung; Li Y; Tam S; Shaipanich T; Raju Rekha; Hague C; Leipsic JA; Bourbeau J; Tan Wan C; Harrigan PR; Sin Don D; Montaner J; Man SFP

Publisher

Plos One

Date

2015

Subject

Female; Humans; Male; Cohort Studies; Adult; Middle Aged; HIV Infections; Pulmonary Disease; Leukocytes; Chronic Obstructive; Cell Aging; Telomere

Description

Combination antiretroviral therapy (cART) has extended the longevity of human immunodeficiency virus (HIV)-infected individuals. However, this has resulted in greater awareness of age-associated diseases such as chronic obstructive pulmonary disease (COPD). Accelerated cellular senescence may be responsible, but its magnitude as measured by leukocyte telomere length is unknown and its relationship to HIV-associated COPD has not yet been established. We measured absolute telomere length (aTL) in peripheral leukocytes from 231 HIV-infected adults. Comparisons were made to 691 HIV-uninfected individuals from a population-based sample. Subject quartiles of aTL were assessed for relationships with measures of HIV disease severity, airflow obstruction, and emphysema severity on computed tomographic (CT) imaging. Multivariable regression models identified factors associated with shortened aTL. Compared to HIV-uninfected subjects, the mean aTL in HIV-infected patients was markedly shorter by 27 kbp/genome (p<0.001); however, the slopes of aTL vs. age were not different (p=0.469). Patients with longer known durations of HIV infection (p=0.019) and lower nadir CD4 cell counts (p=0.023) had shorter aTL. Shorter aTL were also associated with older age (p=0.026), smoking (p=0.005), reduced forced expiratory volume in one second (p=0.030), and worse CT emphysema severity score (p=0.049). HIV-infected subjects demonstrate advanced cellular aging, yet in a cART-treated cohort, the relationship between aTL and age appears no different from that of HIV-uninfected subjects.
2015

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Citation

Liu JCY; Leung JM; Ngan DA; Nashta NF; Guillemi S; Harris M; Lima VD; Um Soo-Jung; Li Y; Tam S; Shaipanich T; Raju Rekha; Hague C; Leipsic JA; Bourbeau J; Tan Wan C; Harrigan PR; Sin Don D; Montaner J; Man SFP, “Absolute leukocyte telomere length in HIV-infected and uninfected individuals: evidence of accelerated cell senescence in HIV-associated chronic obstructive pulmonary disease,” Pediatric Palliative Care Library, accessed January 30, 2023, https://pedpalascnetlibrary.omeka.net/items/show/14508.

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