Human disease classification in the postgenomic era: a complex systems approach to human pathobiology

Title

Human disease classification in the postgenomic era: a complex systems approach to human pathobiology

Creator

Loscalzo J; Kohane I; Barabasi AL

Identifier

Publisher

Molecular Systems Biology

Date

2007

Subject

Humans; Disease; Diagnostic Techniques and Procedures; Genomics; Systems Biology

Description

Contemporary classification of human disease derives from observational correlation between pathological analysis and clinical syndromes. Characterizing disease in this way established a nosology that has served clinicians well to the current time, and depends on observational skills and simple laboratory tools to define the syndromic phenotype. Yet, this time-honored diagnostic strategy has significant shortcomings that reflect both a lack of sensitivity in identifying preclinical disease, and a lack of specificity in defining disease unequivocally. In this paper, we focus on the latter limitation, viewing it as a reflection both of the different clinical presentations of many diseases (variable phenotypic expression), and of the excessive reliance on Cartesian reductionism in establishing diagnoses. The purpose of this perspective is to provide a logical basis for a new approach to classifying human disease that uses conventional reductionism and incorporates the non-reductionist approach of systems biomedicine.
2007

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

124-124

Volume

3

Citation

Loscalzo J; Kohane I; Barabasi AL, “Human disease classification in the postgenomic era: a complex systems approach to human pathobiology,” Pediatric Palliative Care Library, accessed September 25, 2021, https://pedpalascnetlibrary.omeka.net/items/show/14314.

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