Relationship between release of beta-endorphin, cortisol, and trauma severity in children with blunt torso and extremity trauma
Title
Relationship between release of beta-endorphin, cortisol, and trauma severity in children with blunt torso and extremity trauma
Creator
Okur H; Kucukaydn M; Ozokutan BH; Muhtaroglu S; Kazez A; Turan C
Identifier
Publisher
The Journal Of Trauma
Date
2007
Subject
Child; Female; Humans; Male; adolescent; Preschool; infant; beta-Endorphin/blood; Biomarkers of Pain; Biomarkers Reference List; Biological Markers/blood; Wounds; Hydrocortisone/blood; Extremities/injuries; Nonpenetrating/metabolism/surgery; Thoracic Injuries/metabolism/surgery; Trauma Severity Indices
Description
PURPOSE: To determine the levels of beta-endorphin and cortisol in children with multiple injuries and to determine whether there is any difference between and compare the severity of trauma and beta-endorphin and cortisol release as calculated using Pediatric Trauma Score (PTS). METHODS: During a 10-month period, 80 children with multiple injuries admitted to a University Hospital's Pediatric Surgery Department were studied. Blood samples were obtained immediately at admission and a PTS of each patient was calculated. The correlation between PTS and hormonal values were searched. The children were classified into two groups according to their PTS. Group 1 had PTS >8 and group 2 had PTS 0.05). The mean PTS for group 1 patients was 11 +/- 0.8 and for group 2 patients was 7.4 +/- 1.2 (p < 0.001). The mean plasma beta-endorphin concentrations were 124.4 +/- 114.4 pg/mL in group 1 patients and 261.6 +/- 231.2 pg/mL in group 2 (p < 0.001). The respective plasma cortisol concentrations in the two groups were 22.5 +/- 10.3 microg/dL and 30.8 +/- 17.2 microg/dL (p < 0.05), respectively. CONCLUSIONS: The results of this study show that the plasma beta-endorphin and cortisol levels are elevated in children after blunt trauma and the degree of elevation is related to the injury severity.
2007
Rights
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Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Okur H; Kucukaydn M; Ozokutan BH; Muhtaroglu S; Kazez A; Turan C, “Relationship between release of beta-endorphin, cortisol, and trauma severity in children with blunt torso and extremity trauma,” Pediatric Palliative Care Library, accessed March 29, 2024, https://pedpalascnetlibrary.omeka.net/items/show/14202.