Relationship between release of beta-endorphin, cortisol, and trauma severity in children with blunt torso and extremity trauma

Title

Relationship between release of beta-endorphin, cortisol, and trauma severity in children with blunt torso and extremity trauma

Creator

Okur H; Kucukaydn M; Ozokutan BH; Muhtaroglu S; Kazez A; Turan C

Publisher

The Journal Of Trauma

Date

2007

Subject

Child; Female; Humans; Male; adolescent; Preschool; infant; beta-Endorphin/blood; Biomarkers of Pain; Biomarkers Reference List; Biological Markers/blood; Wounds; Hydrocortisone/blood; Extremities/injuries; Nonpenetrating/metabolism/surgery; Thoracic Injuries/metabolism/surgery; Trauma Severity Indices

Description

PURPOSE: To determine the levels of beta-endorphin and cortisol in children with multiple injuries and to determine whether there is any difference between and compare the severity of trauma and beta-endorphin and cortisol release as calculated using Pediatric Trauma Score (PTS). METHODS: During a 10-month period, 80 children with multiple injuries admitted to a University Hospital's Pediatric Surgery Department were studied. Blood samples were obtained immediately at admission and a PTS of each patient was calculated. The correlation between PTS and hormonal values were searched. The children were classified into two groups according to their PTS. Group 1 had PTS >8 and group 2 had PTS 0.05). The mean PTS for group 1 patients was 11 +/- 0.8 and for group 2 patients was 7.4 +/- 1.2 (p < 0.001). The mean plasma beta-endorphin concentrations were 124.4 +/- 114.4 pg/mL in group 1 patients and 261.6 +/- 231.2 pg/mL in group 2 (p < 0.001). The respective plasma cortisol concentrations in the two groups were 22.5 +/- 10.3 microg/dL and 30.8 +/- 17.2 microg/dL (p < 0.05), respectively. CONCLUSIONS: The results of this study show that the plasma beta-endorphin and cortisol levels are elevated in children after blunt trauma and the degree of elevation is related to the injury severity.
2007

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

320--4

Volume

2

Citation

Okur H; Kucukaydn M; Ozokutan BH; Muhtaroglu S; Kazez A; Turan C, “Relationship between release of beta-endorphin, cortisol, and trauma severity in children with blunt torso and extremity trauma,” Pediatric Palliative Care Library, accessed October 27, 2021, https://pedpalascnetlibrary.omeka.net/items/show/14202.

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