Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer
Title
Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer
Creator
Voronov P; Przybylo HJ; Jagannathan N
Identifier
Publisher
Paediatric Anaesthesia
Date
2007
Description
We present a case of a 29 months old previously healthy child who experienced apnea resulting in brain injury following a dose of acetaminophen and codeine 2 days after an uneventful anesthetic for tonsillectomy. A genetic polymorphism leading to ultra-rapid metabolism of codeine into morphine resulted in narcosis and apnea. This paper discusses the use of codeine for pain relief, obstructive sleep apnea, the alteration of the CYP2D6 gene and the resulting effect on drug metabolism.
2007
Rights
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Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Voronov P; Przybylo HJ; Jagannathan N, “Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer,” Pediatric Palliative Care Library, accessed April 24, 2024, https://pedpalascnetlibrary.omeka.net/items/show/14157.