Involvement of cytokines, chemokines and adhesion molecules in opioid analgesia

Title

Involvement of cytokines, chemokines and adhesion molecules in opioid analgesia

Creator

Rittner HL; Stein C

Publisher

European Journal Of Pain

Date

2005

Subject

Humans; Analgesia; Biomarkers of Pain; Receptors; Pain/physiopathology; Cytokines/physiology; Opioid/physiology; Chemokines/physiology; Opioid Peptides/physiology; Pain Threshold/physiology

Description

Tissue destruction is accompanied by an inflammatory reaction. The inflammatory reaction leads to activation of nociceptors and the sensation of pain. Several mediators are responsible for pain and hyperalgesia in inflammation including cytokines, chemokines, nerve growth factor as well as bradykinin, prostaglandins and ATP. Simulatenously however, analgesic mediators are secreted: opioid peptides, somatostatin, endocannabinoids and certain cytokines. Opioid peptides secreted from immune cells are so far the best studied peptides in peripheral inflammatory pain control. This system is hampered for example by anti-adhesion molecule treatment. Novel immunosuppressive drugs for treatment of autoimmune disease targetting cytokines, chemokines or adhesion molecules should therefore be evaluated for potential harmful effects on pain.
2005

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

109-112

Issue

2

Volume

9

Citation

Rittner HL; Stein C, “Involvement of cytokines, chemokines and adhesion molecules in opioid analgesia,” Pediatric Palliative Care Library, accessed September 26, 2021, https://pedpalascnetlibrary.omeka.net/items/show/13729.

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