Are one or two dangerous? Opioid exposure in toddlers

Title

Are one or two dangerous? Opioid exposure in toddlers

Creator

Sachdeva DK; Stadnyk JM

Publisher

The Journal Of Emergency Medicine

Date

2005

Subject

Child; Humans; Analgesics; Preschool; infant; Dose-Response Relationship; Drug; Codeine/poisoning; Emergency Medicine/methods; Fentanyl/poisoning; Methadone/poisoning; Opioid/poisoning; Overdose; Pediatrics/methods; Poisoning/diagnosis/physiopathology/therapy; Tramadol/poisoning

Description

Ingestions of opioid analgesics by children may lead to significant toxicity as a result of depression of the respiratory and central nervous systems. A review of the medical literature was performed to determine whether low doses of opioids are dangerous in the pediatric population under 6 years old. Methadone was found to be the most toxic of the opioids; doses as low as a single tablet can lead to death. All children who have ingested any amount of methadone need to be observed in an Emergency Department (ED) for at least 6 h and considered for hospital admission. Most other opioids are better tolerated in ingestions as small as one or two tablets. Based on the limited data available for these opioids, we conclude that equianalgesic doses of 5 mg/kg of codeine or greater require 4 to 6 h of observation in the ED. Data for propoxyphene and all extended-release preparations are limited; their prolonged half-lives would suggest the need for longer observation periods. All opioid ingestions leading to respiratory depression or significant central nervous system depression require admission to an intensive care unit.
2005

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

77-84

Issue

1

Volume

29

Citation

Sachdeva DK; Stadnyk JM, “Are one or two dangerous? Opioid exposure in toddlers,” Pediatric Palliative Care Library, accessed January 16, 2022, https://pedpalascnetlibrary.omeka.net/items/show/13710.

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