Nociceptin levels in the cerebrospinal fluid of chronic pain patients with or without intrathecal administration of morphine

Title

Nociceptin levels in the cerebrospinal fluid of chronic pain patients with or without intrathecal administration of morphine

Creator

Raffaeli W; Samolsky DBG; Landuzzi D; Caminiti A; Righetti D; Balestri M; Montanari F; Romualdi P; Candeletti S

Publisher

Journal Of Pain And Symptom Management

Date

2006

Subject

Female; Humans; Male; Analgesics; Aged; Middle Aged; Chronic disease; Injections; Opioid/administration & dosage; Spinal; Biological Markers/cerebrospinal fluid; Morphine/administration & dosage; Opioid Peptides/cerebrospinal fluid; Pain Measurement/drug effects/methods; Pain/cerebrospinal fluid/diagnosis/drug therapy

Description

The neuropeptide nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand for the opioid-like receptor ORL-1 and is thought to be involved in pain transmission and modulation. Human studies have not yet defined its role in pain patients. The aims of this study were 1) to verify the presence of N/OFQ in the cerebrospinal fluid (CSF) of human controls and patients with chronic noncancer pain, including those treated with intrathecally administered morphine, and 2) to determine whether pain or treatment with long-term intrathecal morphine influences its levels. The CSF of 27 patients (nine controls and 18 with chronic noncancer pain, of whom 12 were treated chronically with intrathecally administered morphine and six were opioid naive) was analyzed, blindly, with radioimmunoassay methods. N/OFQ was detected in all patients. Mean CSF concentrations were lowest in the morphine-treated group and highest in the untreated chronic pain patients (12.06+/-1.19 and 57.41+/-10.06 fmol/ml, respectively), and the difference between the morphine-treated group and controls was statistically significant (44.72+/-13.56 fmol/ml, P<0.05). The presence of N/OFQ peptide in human CSF may correlate with biological activities that are influenced by different pain states and long-term intrathecal-morphine treatment. Further studies should verify whether the determination of this peptide CSF level may provide information on opioid treatment efficacy and on the presence of opioid tolerance.
2006

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

372-377

Issue

4

Volume

32

Citation

Raffaeli W; Samolsky DBG; Landuzzi D; Caminiti A; Righetti D; Balestri M; Montanari F; Romualdi P; Candeletti S, “Nociceptin levels in the cerebrospinal fluid of chronic pain patients with or without intrathecal administration of morphine,” Pediatric Palliative Care Library, accessed September 18, 2021, https://pedpalascnetlibrary.omeka.net/items/show/13705.

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