Gastric sensory and motor dysfunction in adolescents with functional dyspepsia

Gastric sensory and motor dysfunction in adolescents with functional dyspepsia

Chitkara DK; Camilleri M; Zinsmeister AR; Burton D; El-Youssef M; Freese D; Walker L; Stephens D

The Journal Of Pediatrics

2005

Female; Humans; Male; adolescent; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; Emission-Computed; Tomography; Receptors; Breath Tests; Dyspepsia/physiopathology; Gastric Emptying; Sensory/physiopathology; Single-Photon; Stomach/physiopathology

OBJECTIVES: Validated, noninvasive studies were used to compare sensation and motor function of the upper gastrointestinal tract in adolescents with functional dyspepsia (FD) and in control subjects. STUDY DESIGN: Fifteen adolescents with FD and 15 healthy participants underwent standardized symptom assessment, a satiation nutrient drink test, and 13 C-Spirulina platensis breath test for gastric emptying of solids. Adolescents with FD also underwent measurements of fasting and postprandial gastric volume by means of single-photon emission computed tomography, and their results were compared with those from 15 healthy volunteers (age, 18 to 25 years). RESULTS: Compared with control subjects, adolescents with FD had significantly higher postprandial symptoms 30 minutes after reaching maximum satiation with the nutrient drink test and significant delay in the T 1/2 for gastric emptying of solids. Compared with healthy 18- to 25-year-old adults, adolescents had a diminished postprandial gastric volume response. By means of single-photon emission computed tomography, frequent baseline dyspeptic symptoms were associated with prolonged T 1/2 for gastric emptying and higher postprandial aggregate symptom score. A baseline increased severity of dyspepsia symptoms was associated with prolonged T 1/2 for gastric emptying. CONCLUSIONS: Adolescents with FD demonstrate increased postprandial symptoms after challenge, delayed gastric emptying, and a reduced gastric volume response to feeding.

2005

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