Glia: novel counter-regulators of opioid analgesia

Title

Glia: novel counter-regulators of opioid analgesia

Creator

Watkins LR; Hutchinson MR; Johnston IN; Maier SF

Publisher

Trends In Neurosciences

Date

2005

Subject

Humans; Analgesics; Animals; Opioid/administration & dosage; Drug Tolerance; Brain/drug effects/metabolism; Neuroglia/drug effects/metabolism; Neurotransmitter Agents/metabolism; Nociceptors/drug effects/metabolism; Pain/metabolism/prevention & control; Spinal Cord/drug effects/metabolism

Description

Development of analgesic tolerance and withdrawal-induced pain enhancement present serious difficulties for the use of opioids for pain control. Although neuronal mechanisms to account for these phenomena have been sought for many decades, their bases remain unresolved. Within the past four years, a novel non-neuronal candidate has been uncovered that opposes acute opioid analgesia and contributes to development of opioid tolerance and tolerance-associated pain enhancement. This novel candidate is spinal cord glia. Glia are important contributors to the creation of enhanced pain states via the release of neuroexcitatory substances. New data suggest that glia also release neuroexcitatory substances in response to morphine, thereby opposing its effects. Controlling glial activation could therefore increase the clinical utility of analgesic drugs.
2005

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

661-669

Issue

12

Volume

28

Citation

Watkins LR; Hutchinson MR; Johnston IN; Maier SF, “Glia: novel counter-regulators of opioid analgesia,” Pediatric Palliative Care Library, accessed May 18, 2022, https://pedpalascnetlibrary.omeka.net/items/show/13656.

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