Individual responder analyses for pain: does one pain scale fit all?

Title

Individual responder analyses for pain: does one pain scale fit all?

Creator

Dionne RA; Bartoshuk L; Mogil J; Witter J

Publisher

Trends In Pharmacological Sciences

Date

2005

Subject

Humans; Reproducibility of Results; P.H.S.; Research Support; U.S. Gov't; Comparative Study; Pain/drug therapy/physiopathology; Clinical Trials/methods/trends; Pain Measurement/drug effects/methods/standards

Description

The outcomes of clinical trials are based on the mean responses of large numbers of subjects but fail to address inter-individual differences. The molecular mechanisms that underlie pain vary among individuals over time and among different types of pain to produce wide inter-individual variations in pain perception and response. Gender, ethnicity, temperament and genetic factors also contribute to individual variation in pain sensitivity and responses to analgesics. Pain measurement scales can be used differently across individuals based on the past pain experiences of individuals. We propose that individual responder analyses could be used in clinical trials to better detect analgesic activity across patient groups and within sub-groups, and to identify molecular-genetic mechanisms that contribute to individual variation.
2005

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

125-130

Issue

3

Volume

26

Citation

Dionne RA; Bartoshuk L; Mogil J; Witter J, “Individual responder analyses for pain: does one pain scale fit all?,” Pediatric Palliative Care Library, accessed July 4, 2022, https://pedpalascnetlibrary.omeka.net/items/show/13655.

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