Should domperidone be used for the treatment of gastro-oesophageal reflux in children? Systematic review of randomized controlled trials in children aged 1 month to 11 years old

Title

Should domperidone be used for the treatment of gastro-oesophageal reflux in children? Systematic review of randomized controlled trials in children aged 1 month to 11 years old

Creator

Pritchard DS; Baber N; Stephenson T

Publisher

British Journal of Clinical Pharmacology

Date

2005

Subject

PedPal Lit; 'improved' or 'unchanged'. The secondary pH-metric outcome of the number of reflux episodes; a good or excellent result was obtained in 93% of the domperidone group compared with 33% of the controls (P < 0.05). In the trial undertaken by de Loore; after 2 weeks of treatment 75% of patients treated with domperidone were found not to be vomiting; and reference citations of the RCTs that had been found electronically. RESULTS: Four RCTs were identified. Only the two older trials showed any benefits of domperidone on clinical symptoms of GORD in older children; Antiemetics/therapeutic use Child Child; compared with 43% in the metoclopramide group and 7% in the placebo group. The trial by Corraccio gave no detailed results regarding the primary outcomes of effect of domperidone on symptoms but simply reported 'cured'; drug therapy Humans Infant Randomized Controlled Trials/methods Research Design Treatment Outcome; Medline (Pub-med) 1966 to present and Embase from 1974 to 2004; Preschool Domperidone/; the widespread use of unlicensed medicines for GOR is not warranted.; therapeutic use Dopamine Antagonists/; therapeutic use Evidence-Based Medicine Gastroesophageal Reflux/; there was no robust evidence of efficacy for the treatment of GOR with domperidone in young children. Given the usually benign nature of the condition; was reduced with domperidone. CONCLUSION: From the limited evidence available; which were the primary outcome measures. In the trial undertaken by Clara

Description

2005

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

725-9

Issue

6

Volume

59

Tags

, , , , , , , , , , , , , , , , , , , , ,

Citation

Pritchard DS; Baber N; Stephenson T, “Should domperidone be used for the treatment of gastro-oesophageal reflux in children? Systematic review of randomized controlled trials in children aged 1 month to 11 years old,” Pediatric Palliative Care Library, accessed May 19, 2022, https://pedpalascnetlibrary.omeka.net/items/show/13494.

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