Abdominal pain related to mitochondrial neurogastrointestinal encephalomyopathy syndrome may benefit from splanchnic nerve blockade

Title

Abdominal pain related to mitochondrial neurogastrointestinal encephalomyopathy syndrome may benefit from splanchnic nerve blockade

Creator

Celebi N; Sahin A; Canbay O; Uzumcugil F; Aypar U

Publisher

Paediatric Anaesthesia

Date

2006

Subject

Humans; Male; Magnetic Resonance Imaging; Nerve Block; Anesthetics; adolescent; Electromyography; Neurologic Examination; Analgesics/therapeutic use; Local; Amines/therapeutic use; Cyclohexanecarboxylic Acids/therapeutic use; gamma-Aminobutyric Acid/therapeutic use; Abdominal Pain/etiology/therapy; Gastrointestinal Diseases/complications/radiography; Mitochondrial Encephalomyopathies/complications/radiography; Paresthesia/etiology; Prilocaine; Splanchnic Nerves

Description

Patients diagnosed with abdominal pain related to mitochondrial neurogastrointestinal encephalopathy (MNGIE) may benefit from splanchnic nerve blockade. MNGIE, varying in age of onset and rate of progression, is caused by loss of function mutation in thymidine phosphorylase gene. Gastrointestinal dysmotility, pseudo-obstruction and demyelinating sensorimotor peripheral neuropathy (stocking-glove sensory loss, absent tendon reflexes, distal limb weakness, and wasting) are the most prominent manifestations. Patients usually die in early adulthood (mean 37.6 years; range 26-58 years). We report a case of an 18-year-old patient with MNGIE. Our patient's abdominal pain was relieved after splanchnic nerve blockade.
2006

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

1073-1076

Issue

10

Volume

16

Citation

Celebi N; Sahin A; Canbay O; Uzumcugil F; Aypar U, “Abdominal pain related to mitochondrial neurogastrointestinal encephalomyopathy syndrome may benefit from splanchnic nerve blockade,” Pediatric Palliative Care Library, accessed October 24, 2021, https://pedpalascnetlibrary.omeka.net/items/show/13458.

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