Abdominal pain related to mitochondrial neurogastrointestinal encephalomyopathy syndrome may benefit from splanchnic nerve blockade
Title
Abdominal pain related to mitochondrial neurogastrointestinal encephalomyopathy syndrome may benefit from splanchnic nerve blockade
Creator
Celebi N; Sahin A; Canbay O; Uzumcugil F; Aypar U
Identifier
Publisher
Paediatric Anaesthesia
Date
2006
Subject
Humans; Male; Magnetic Resonance Imaging; Nerve Block; Anesthetics; adolescent; Electromyography; Neurologic Examination; Analgesics/therapeutic use; Local; Amines/therapeutic use; Cyclohexanecarboxylic Acids/therapeutic use; gamma-Aminobutyric Acid/therapeutic use; Abdominal Pain/etiology/therapy; Gastrointestinal Diseases/complications/radiography; Mitochondrial Encephalomyopathies/complications/radiography; Paresthesia/etiology; Prilocaine; Splanchnic Nerves
Description
Patients diagnosed with abdominal pain related to mitochondrial neurogastrointestinal encephalopathy (MNGIE) may benefit from splanchnic nerve blockade. MNGIE, varying in age of onset and rate of progression, is caused by loss of function mutation in thymidine phosphorylase gene. Gastrointestinal dysmotility, pseudo-obstruction and demyelinating sensorimotor peripheral neuropathy (stocking-glove sensory loss, absent tendon reflexes, distal limb weakness, and wasting) are the most prominent manifestations. Patients usually die in early adulthood (mean 37.6 years; range 26-58 years). We report a case of an 18-year-old patient with MNGIE. Our patient's abdominal pain was relieved after splanchnic nerve blockade.
2006
Rights
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Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Celebi N; Sahin A; Canbay O; Uzumcugil F; Aypar U, “Abdominal pain related to mitochondrial neurogastrointestinal encephalomyopathy syndrome may benefit from splanchnic nerve blockade,” Pediatric Palliative Care Library, accessed February 7, 2025, https://pedpalascnetlibrary.omeka.net/items/show/13458.