Molecular pathways leading to cancer cachexia

Molecular pathways leading to cancer cachexia

Tisdale MJ

Physiology (bethesda)

2005

Humans; Animals; Cachexia/etiology/metabolism; Muscle; Blood Proteins/metabolism; Cytokines/metabolism; Adipose Tissue/metabolism; Neoplasms/complications/metabolism; Peptides/metabolism; Skeletal/metabolism

Loss of body weight in cancer patients strongly influences morbidity and mortality. Recent studies have suggested that both tumor and host factors play a major role in tissue catabolism in cachexia, leading to upregulation of degradative pathways in both skeletal muscle and adipose tissue.

2005

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