Safety of polyethylene glycol 3350 for the treatment of chronic constipation in children
Title
Safety of polyethylene glycol 3350 for the treatment of chronic constipation in children
Creator
Pashankar DS; Loening-Baucke V; Bishop WP
Identifier
Publisher
Archives Of Pediatrics & Adolescent Medicine
Date
2003
Subject
Child; Female; Humans; Male; Questionnaires; Prospective Studies; Patient Compliance; adolescent; Preschool; Non-U.S. Gov't; Research Support; Chronic disease; Alanine Transaminase/blood; Cathartics/therapeutic use; Constipation/drug therapy; Encopresis/drug therapy; Polyethylene Glycols/therapeutic use
Description
OBJECTIVES: To assess the clinical and biochemical safety profile of long-term polyethylene glycol 3350 (PEG) therapy in children with chronic constipation and to assess pediatric patient acceptance of PEG therapy. DESIGN: Prospective observational study. SETTING: Pediatric clinics at a referral center.Patients Eighty-three children (44 with chronic constipation, 39 with constipation and encopresis) receiving PEG therapy for more than 3 months. MAIN OUTCOME MEASURES: Clinical adverse effects related to PEG therapy and acceptance and compliance with PEG therapy. Serum electrolyte levels, osmolality, albumin levels, and liver and renal function test results were measured. RESULTS: At the time of evaluation, the mean duration of PEG therapy was 8.7 months, and the mean PEG dose was 0.75 g/kg daily. There were no major clinical adverse effects. All blood test results were normal, except for transient minimal alanine aminotransferase elevation unrelated to therapy in 9 patients. All children preferred PEG to previously used laxatives, and daily compliance was measured as good in 90% of children. CONCLUSIONS: Long-term PEG therapy is safe and is well accepted by children with chronic constipation with and without encopresis.
2003
Rights
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Pashankar DS; Loening-Baucke V; Bishop WP, “Safety of polyethylene glycol 3350 for the treatment of chronic constipation in children,” Pediatric Palliative Care Library, accessed February 11, 2025, https://pedpalascnetlibrary.omeka.net/items/show/13115.