Opioids in renal failure and dialysis patients

Title

Opioids in renal failure and dialysis patients

Creator

Dean M

Publisher

Journal Of Pain And Symptom Management

Date

2004

Subject

Humans; Analgesics; Pain/drug therapy; Opioid/therapeutic use; Chronic/complications/therapy; Kidney Failure; Peritoneal Dialysis

Description

This article reviews the literature pertaining to the metabolism of several of the commonly used opioids, and the known activity of their metabolites. The effect of renal failure on the pharmacokinetics of these drugs and metabolites is then reviewed. Finally, the effect of renal dialysis on opioid drugs and metabolites is reviewed. Based on the review, it is recommended that morphine and codeine are avoided in renal failure/dialysis patients; hydromorphone or oxycodone are used with caution and close monitoring; and that methadone and fentanyl/sufentanil appear to be safe to use. Note is made that the "safe" drugs in renal failure are also the least dialyzable.
2004

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

497-504

Issue

5

Volume

28

Citation

Dean M, “Opioids in renal failure and dialysis patients,” Pediatric Palliative Care Library, accessed May 22, 2022, https://pedpalascnetlibrary.omeka.net/items/show/13048.

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