Neurohormonal factors in the development of catabolic/anabolic imbalance and cachexia
Title
Neurohormonal factors in the development of catabolic/anabolic imbalance and cachexia
Creator
Brink M; Anwar A; Delafontaine P
Identifier
Publisher
International Journal Of Cardiology
Date
2002
Subject
Humans; Animals; Heart Failure; Cachexia/etiology/metabolism; Neurotransmitter Agents/metabolism; Biological Markers/blood; Congestive/complications/metabolism; Cytokines/metabolism; Glucocorticoids/metabolism; Insulin-Like Growth Factor I/metabolism; Renin-Angiotensin System/physiology
Description
Mechanisms that lead to cachexia are still poorly understood. The neurohormonal changes that occur in severe disease states may cause an imbalance between protein synthesis and degradation at the cellular level, followed by muscle wasting. Here, we review actions of angiotensin II, TNF-alpha, corticosteroids, insulin-like growth factor-I (IGF-I), and the IGF binding proteins, factors that may each contribute to the metabolic imbalance. The complex endocrine, autocrine and intracellular interactions between these factors will be described with examples from patient, rat and cell culture studies. Moreover, some of the data supporting that each of these hormones may directly affect cellular protein degradation mechanisms will be reviewed. Knowledge on these regulatory mechanisms will facilitate the development of new pharmaceutical strategies to treat cachexia.
2002
Rights
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Brink M; Anwar A; Delafontaine P, “Neurohormonal factors in the development of catabolic/anabolic imbalance and cachexia,” Pediatric Palliative Care Library, accessed June 9, 2023, https://pedpalascnetlibrary.omeka.net/items/show/13023.