A prospective comparative study of 2540 infants and children with newly diagnosed idiopathic thrombocytopenic purpura (ITP) from the Intercontinental Childhood ITP Study Group

A prospective comparative study of 2540 infants and children with newly diagnosed idiopathic thrombocytopenic purpura (ITP) from the Intercontinental Childhood ITP Study Group

Kuhne T; Buchanan GR; Zimmerman S; Michaels LA; Kohan R; Berchtold W; Imbach P; Intercontinental Childhood ITP Study Group; Intercontinental Childhood ITP Study Group

The Journal Of Pediatrics

2003

Child; Female; Humans; Male; Questionnaires; Follow-Up Studies; Prospective Studies; Incidence; adolescent; infant; Age Distribution; Purpura; Thrombocytopenic; Anti-Inflammatory Agents/therapeutic use; Idiopathic/drug therapy/epidemiology; Immunoglobulins; Intravenous/administration & dosage/therapeutic use

OBJECTIVE: To analyze prospectively the impact of age at diagnosis in childhood idiopathic thrombocytopenic purpura (ITP). STUDY DESIGN: International registry from June 1997 to May 2001, with analysis of data from baseline and 6-month-follow-up questionnaires. RESULTS: Data from 2540 patients were analyzed, including 203 infants (7.6%), 1860 children > or =1 to or =10 and or =10 and or =10 years of age. Follow-up information at 6 months was available for 1742 children (68.6%). Chronic ITP was seen less frequently in infants (23.1%) than in children >10 years of age (47.3%, P<.0001). Intracranial hemorrhage occurred in 3 of 1742 children during the first 6 months after the diagnosis of ITP. CONCLUSIONS: Pediatric patients with ITP from infancy to adolescence exhibit heterogeneity in clinical, demographic, and treatment factors.

2003

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