Nitric oxide as a prognostic marker for neurological diseases

Title

Nitric oxide as a prognostic marker for neurological diseases

Creator

Bratasz A; Kuter I; Konior R; Goscinski I; Lukiewicz S

Publisher

Antioxidants & Redox Signaling

Date

2004

Subject

Child; Humans; Adult; Prognosis; Animals; Biomarkers of Pain; Brain/pathology; Children W/SNI; Brain Neoplasms/cerebrospinal fluid/diagnosis; Cerebrospinal Fluid; Craniocerebral Trauma/cerebrospinal fluid/diagnosis; Electron Spin Resonance Spectroscopy/methods; Meningitis/cerebrospinal fluid/diagnosis; Nervous System Diseases/cerebrospinal fluid/diagnosis/mortality; Nitric Oxide/cerebrospinal fluid/metabolism

Description

The potential value of the nitric oxide (NO) level as a prognostic marker in human brain diseases is investigated. Cerebrospinal fluid (CSF) collected from neurological patients was examined for NO content using electron paramagnetic resonance (EPR) spectroscopy. In adult patients with meningitis, the level of NO was higher than that in other groups of brain disorders, such as brain traumas and brain tumors. Very high levels of NO in the CSF appeared to be correlated with a high incidence of fatal outcomes. In children with meningitis, it was possible to differentiate between viral and bacterial origin of the disease as evidenced by the EPR analysis of the CSF. The results indicated that NO levels in the CSF can be a useful prognostic marker in neurological diseases.
2004

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

613-617

Issue

3

Volume

6

Citation

Bratasz A; Kuter I; Konior R; Goscinski I; Lukiewicz S, “Nitric oxide as a prognostic marker for neurological diseases,” Pediatric Palliative Care Library, accessed September 28, 2021, https://pedpalascnetlibrary.omeka.net/items/show/12862.

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