Rheumatoid cachexia: metabolic abnormalities, mechanisms and interventions

Title

Rheumatoid cachexia: metabolic abnormalities, mechanisms and interventions

Creator

Rall LC; Roubenoff R

Publisher

Rheumatology

Date

2004

Subject

Humans; Exercise Therapy; Arthritis; Energy Metabolism/physiology; Intervention; Interventions; Proteins/metabolism; Aging/physiology; Cachexia/complications/metabolism/therapy; Cytokines/antagonists & inhibitors/metabolism; Diet; Hormones/metabolism; Rheumatoid/complications/metabolism/therapy

Description

We have previously identified the phrase 'rheumatoid cachexia' to describe the loss of body cell mass (BCM) that may occur among patients with rheumatoid arthritis (RA). Specifically, rheumatoid cachexia is characterized by altered energy and protein metabolism (reduced total energy expenditure, increased resting energy expenditure and increased whole-body protein catabolism) and increased inflammatory cytokine production (interleukin-1beta and tumour necrosis factor-alpha). Patients with rheumatoid cachexia consistently have a diet that appears adequate in protein and calories (based on US Dietary Reference Intakes), but with reduced physical activity. These phenomena are similar to some of the metabolic abnormalities that occur with normal ageing, but the aetiology appears to be different in RA. This review will focus on describing the metabolic abnormalities observed in rheumatoid cachexia, identifying potential mechanisms for loss of BCM and discussing strategies for intervention.
2004

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

1219-1223

Issue

10

Volume

43

Citation

Rall LC; Roubenoff R, “Rheumatoid cachexia: metabolic abnormalities, mechanisms and interventions,” Pediatric Palliative Care Library, accessed September 21, 2021, https://pedpalascnetlibrary.omeka.net/items/show/12848.

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