Beta endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis

Title

Beta endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis

Creator

Gironi M; Furlan R; Rovaris M; Comi G; Filippi M; Panerai AE; Sacerdote P

Publisher

Journal Of Neurology, Neurosurgery, And Psychiatry

Date

2003

Subject

Female; Humans; Male; Adult; Middle Aged; Magnetic Resonance Imaging; Phenotype; Biomarkers of Pain; Brain/pathology; Leukocytes; Mononuclear/chemistry; beta-Endorphin/blood/genetics; Multiple Sclerosis/blood/genetics/pathology

Description

The possible link between the opioid peptide beta endorphin and the heterogeneity of the clinical course of multiple sclerosis (MS) was investigated. Peripheral blood mononuclear cells (PBMC) concentrations of beta endorphin were measured in 50 patients in different phases of MS. Thirty nine patients also underwent post-contrast magnetic resonance imaging of the brain. Among MS forms, the highest beta endorphin concentrations were found in PBMC from patients with relapsing remitting MS and the lowest in patients with the progressive forms. Average beta endorphin concentrations were lower, although not significantly, in patients with than in those without magnetic resonance imaging enhanced lesions. These data suggest that beta endorphin may have a role in the downregulation of the inflammatory process.
2003

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

495-497

Issue

4

Volume

74

Citation

Gironi M; Furlan R; Rovaris M; Comi G; Filippi M; Panerai AE; Sacerdote P, “Beta endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis,” Pediatric Palliative Care Library, accessed September 18, 2021, https://pedpalascnetlibrary.omeka.net/items/show/12748.

Social Bookmarking