The efficacy and side effects of continuous infusion intravenous morphine (CIVM) for pain and symptoms due to advanced cancer

The efficacy and side effects of continuous infusion intravenous morphine (CIVM) for pain and symptoms due to advanced cancer

Glare P; Walsh D; Groh E; Nelson KA

The American Journal Of Hospice & Palliative Care

2002

Female; Humans; Male; United States; Pain; Adult; Analgesics; Aged; Middle Aged; 80 and over; retrospective studies; Palliative Care/methods; Infusions; Intravenous; Opioid/administration & dosage/adverse effects; Intractable/drug therapy/etiology; Morphine/administration & Neoplasms/complications

Morphine is the strong opioid of choice in the management of moderate-to-severe chronic cancer pain. The preferred route of administration is oral, in individually titrated doses, regularly scheduled around the clock We conducted a retrospective study of continuous intravenous morphine (CIVM) in a palliative medicine program in 107 consecutive patients. The results suggest CIVM is an effective, safe, and versatile method of morphine administration when used with a defined protocol. Efficacy was similar to that obtained by others with intravenous morphine sulfate and also for oral morphine. Safety was suggested by the low incidence of dose-limiting side effects, most of which responded to dose reduction. Particularly noteworthy was the flexibility of CIVM with dose reduction in 20 percent.

2002

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