Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions

Title

Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions

Creator

Raffin-Sanson ML; de Keyzer Y; Bertagna X

Publisher

European Journal Of Endocrinology

Date

2003

Subject

Female; Humans; Pregnancy; Animals; Biomarkers of Pain; Nervous System Diseases/physiopathology; Neuropeptides/metabolism; Pro-Opiomelanocortin/biosynthesis/genetics/physiology

Description

Proopiomelanocortin (POMC) is the polypeptide precursor of ACTH. First discovered in anterior pituitary corticotroph cells, it has more recently been revealed to have many other physiological aspects. The fine molecular mechanisms of ACTH biosynthesis show that ACTH is but one piece of a puzzle which contains many other peptides. Present in various tIssues, among which are pituitary, hypothalamus, central nervous system and skin, POMC undergoes extensive post-translational processing. This processing is tIssue-specific and generates, depending on the case, various sets of peptides involved in completely diverse biological functions. POMC expressed in corticotroph cells of the pituitary is necessary for adrenal function. Recent developments have shown that POMC-expressing neurons in the brain play a major role in the control of pain and energy homeostasis. Local production of POMC-derived peptides in skin may influence melanogenesis. A still unknown function in the placenta is likely.POMC has become a paradigmatic polypeptide precursor model illustrating the variable roles of a single gene and its various products in different localities.
2003

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Citation

Raffin-Sanson ML; de Keyzer Y; Bertagna X, “Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions,” Pediatric Palliative Care Library, accessed September 28, 2022, https://pedpalascnetlibrary.omeka.net/items/show/12661.

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