Wilson's disease: a longitudinal study of psychiatric symptoms

Title

Wilson's disease: a longitudinal study of psychiatric symptoms

Creator

Dening TR; Berrios GE

Publisher

Biological Psychiatry

Date

1990

Subject

Female; Humans; Male; Cohort Studies; Adult; Follow-Up Studies; Longitudinal Studies; Delirium; Dementia; adolescent; IM; retrospective studies; Neuropsychological Tests; Amnestic; Cognitive Disorders/di [Diagnosis]; Cognitive Disorders/px [Psychology]; Hepatolenticular Degeneration/di [Diagnosis]; Hepatolenticular Degeneration/px [Psychology]; Liver Function Tests; Neurologic Examination

Description

One hundred and twenty-nine cases of Wilson's disease (WD) were assessed at index admission and two follow-ups (F1 and F2) on a range of clinical and biochemical variables. The commonest psychiatric symptoms throughout were incongruous behavior, irritability, depression, and cognitive impairment. Among psychiatric cases, most improvements occurred in the interval index-F1, with subsequent leveling off. Significant improvement occurred only with incongruous behavior and cognitive impairment. Psychiatric cases whose psychiatric symptoms persisted to F2 differed from those who responded, in particular showing more dysarthria, incongruous behavior, and hepatic symptoms. Neuropsychiatric cases displayed more dysarthria and incongruous behavior than patients with neurological symptoms alone. Further evidence for associations between dysarthria and abnormal behavior emerged from this study.
1990

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

255-265

Issue

3

Volume

28

Citation

Dening TR; Berrios GE, “Wilson's disease: a longitudinal study of psychiatric symptoms,” Pediatric Palliative Care Library, accessed June 25, 2022, https://pedpalascnetlibrary.omeka.net/items/show/12543.

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