Plasma beta-endorphin during fasting in man

Title

Plasma beta-endorphin during fasting in man

Creator

Komaki G; Tamai H; Sumioki H; Mori T; Kobayashi N; Mori K; Mori S; Nakagawa T

Identifier

Publisher

Hormone Research

Date

1990

Subject

Female; Humans; Male; Adult; adolescent; Body Weight; beta-Endorphin/blood; Homeostasis/drug effects; Creatinine/blood; Hydrocortisone/blood; Blood Urea Nitrogen; Cholesterol/blood; Fasting/metabolism; Uric Acid/blood

Description

To identify the effects of acute starvation on endogenous opioids in man, plasma beta-endorphin (beta-EP) was measured in 17 patients before, during and after fasting. Patients were assigned a posteriori into two groups: group A, comprised of 11 patients able to tolerate 5-7 days of fasting, and group B, comprised of 6 patients able to tolerate 10 days of fasting. Changes in plasma beta-EP, serum cortisol, circulating nutritional markers, and their relative levels were assessed on the 5th and 10th days of fasting, and on the 5th and 10th days of the refeeding period. Beta-EP had increased by the 5th day (group A: 4.74 +/- 0.42 to 6.91 +/- 0.65 pmol/l, p less than 0.01; group B: 3.60 +/- 0.48 to 5.14 +/- 0.22 pmol/l, p less than 0.05, and remained at 5.05 +/- 0.65 pmol/l on the 10th day (group B: 0.05 less than p less than 0.1) during fasting. Group B had lower levels of plasma beta-EP on the 5th day of fasting than group A (p less than 0.05). However, serum cortisol levels changed similarly in both groups. Plasma beta-EP showed no significant correlation with either the percentage of body weight lost or the body mass index (kg/m2) over this study period. These findings indicate that plasma beta-EP is elevated in the early phase of fasting, while not directly being associated with body weight changes. Plasma beta-EP is lower and less activated in subjects who are able to tolerate fasting for longer periods.
1990

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

239-243

Issue

6

Volume

33

Citation

Komaki G; Tamai H; Sumioki H; Mori T; Kobayashi N; Mori K; Mori S; Nakagawa T, “Plasma beta-endorphin during fasting in man,” Pediatric Palliative Care Library, accessed July 2, 2022, https://pedpalascnetlibrary.omeka.net/items/show/12445.

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