Tay-Sachs disease: Progression of changes on neuroimaging in four cases.

Title

Tay-Sachs disease: Progression of changes on neuroimaging in four cases.

Creator

Fukumizu M; Yoshikawa H; Takashima S; Sakuragawa N; Kurokawa T

Identifier

Publisher

Neuroradiology

Date

1992

Subject

Child; Humans; Male; Follow-Up Studies; Longitudinal Studies; Magnetic Resonance Imaging; Preschool; infant; Brain Diseases; Emission-Computed; Tomography; Brain/pathology; Atrophy; X-Ray Computed; Demyelinating Diseases/diagnosis/pathology; Metabolic/diagnosis/pathology; Tay-Sachs Disease/diagnosis/pathology

Description

The neuroradiological findings in four patients with Tay-Sachs disease are described in three phases of the clinical course. The basal ganglia and cerebral white matter show low density on computed tomography and high signal intensity on T2-weighted magnetic resonance imaging in the initial phase. The caudate nuclei are characteristically enlarged and protrude into the lateral ventricles in the first and second phases. The cerebral white matter shows low density on the CT which varies in extent from the second to third phases, and the whole brain becomes atrophic in the last phase. Thus, central nervous system involvement in the disease may begin in basal ganglia as well as in cerebral white matter.
1992

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

483-486

Issue

6

Volume

34

Citation

Fukumizu M; Yoshikawa H; Takashima S; Sakuragawa N; Kurokawa T, “Tay-Sachs disease: Progression of changes on neuroimaging in four cases.,” Pediatric Palliative Care Library, accessed June 27, 2022, https://pedpalascnetlibrary.omeka.net/items/show/12316.

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