Age-related changes of beta-endorphin and cholecystokinin in human and rat mononuclear cells

Age-related changes of beta-endorphin and cholecystokinin in human and rat mononuclear cells

Sacerdote P; Breda M; Barcellini W; Meroni PL; Panerai AE

Peptides

1991

Humans; Male; Adult; Aged; Middle Aged; Animals; Rats; 80 and over; beta-Endorphin/blood; Lymphocyte Activation; Aging/blood/immunology; Cholecystokinin/blood; In Vitro; Interleukin-2/biosynthesis; Leukocytes; Mononuclear/immunology/metabolism

Beta-endorphin (BE) and cholecystokinin (CCK) were measured in fresh PBMC isolated from human subjects and rats. The BE and CCK PBMC contents increased significantly with age both in human and rat models. Moreover, polyclonal stimulation induced a significant decrease of BE but not CCK contents in mononuclear cells from human aged subjects. The time course of changes in BE and CCK concentrations observed in fresh and cultured cells from subjects of different ages did not directly correlate to the time course of age-associated impairment of lectin-induced lymphocyte proliferative response and interleukin-2 synthesis. In fact, the lymphocyte functional defects were significantly observed only in the 71-99 year age group, whereas the neuropeptide changes were already evident in the 31-50 age group. Since BE has been shown to participate in the modulation of the immune system, the age-related modifications of PBMC BE could play a role in the immunodepression observed during aging.

1991

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Journal Article

Backlog