Acute onset of X-linked adrenoleukodystrophy mimicking encephalitis
Title
Acute onset of X-linked adrenoleukodystrophy mimicking encephalitis
Creator
Zammarchi E; Donati MA; Tucci F; Fonda C; Fanelli F; Pazzaglia R
Identifier
Publisher
Brain & Development
Date
1994
Subject
Humans; Male; Acute Disease; infant; Q3 Literature Search; Tomography; Diagnosis; Differential; X-Ray Computed; Adrenoleukodystrophy/diagnosis/drug therapy/genetics; Encephalitis/diagnosis; Erucic Acids/therapeutic use; Fatty Acids/blood; Linkage (Genetics); X Chromosome
Description
We report the case of a 6-year-old boy with X-linked adrenoleukodystrophy (ALD). In view of the acute onset of vomiting, fever, and coma, encephalitis was initially suspected. However, brain magnetic resonance imaging demonstrated a pattern of demyelination that was consistent with ALD; this diagnosis was confirmed by the finding of elevated plasma very long-chain fatty acids levels. At presentation, the patient was hyponatremic. That this metabolic disturbance and the coma resolved within hours of the initiation of corticosteroid therapy suggests that the presenting symptoms were secondary to adrenal cortical insufficiency. Primary adrenal failure was confirmed by endocrinologic evaluation. Thrombocytopenia, hepatic transaminase abnormalities, anemia and leukopenia developed during the subsequent course of therapy with oleic acid and erucic acid.
1994
Rights
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Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Zammarchi E; Donati MA; Tucci F; Fonda C; Fanelli F; Pazzaglia R, “Acute onset of X-linked adrenoleukodystrophy mimicking encephalitis,” Pediatric Palliative Care Library, accessed April 24, 2024, https://pedpalascnetlibrary.omeka.net/items/show/12287.