High-dose oral morphine in cancer pain management: a report of twelve cases

High-dose oral morphine in cancer pain management: a report of twelve cases

Radbruch L; Grond S; Zech DJ; Bischoff A

Journal of Clinical Anesthesia

1996

Female; Male; Pain; Analgesics; Aged; Fatal Outcome; Non-U.S. Gov't; Human; Case Report; Support; Intractable/drug therapy/etiology; Middle Age; Morphine/administration & dosage/adverse effects/therapeutic use; Neoplasms/complications; Opioid/administration & dosage/adverse effects/therapeutic; use

We present 12 case reports from patients treated with more than 600 mg of morphine per day. We found no "opioid-nonresponsive pain" under treatment with a combination of morphine and nonopioids, supplemented with coanalgesics where appropriate. Side effects of morphine therapy were controlled with adjuvant drugs. Serious adverse effects were not observed. Episodes of break-through pain, dysphagia, and dyspnea caused by far advanced cancer disease were seen frequently.

1996

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