The clinical course of childhood and adolescent adrenoleukodystrophy before and after Lorenzo's oil

Title

The clinical course of childhood and adolescent adrenoleukodystrophy before and after Lorenzo's oil

Creator

Suzuki Y; Imamura A; Shimozawa N; Kondo N

Publisher

Brain & Development

Date

2001

Subject

Child; Humans; Male; Treatment Outcome; Disease Progression; Japan; adolescent; Q3 Literature Search; Erucic Acids/therapeutic use; Adrenoleukodystrophy/drug therapy/pathology/physiopathology

Description

The clinical course of Japanese patients with childhood and adolescent adrenoleukodystrophy (ALD) who were treated with Lorenzo's oil after the progression of early symptoms was investigated by Kaplan-Meier analyses. Many of the early symptoms, including visual, personality, hearing, mental and speech disturbances, had already appeared when the oil therapy was started. These early symptoms appeared significantly faster than bed-ridden state or dysphagia (P<0.01). Gait disturbance appeared faster than bed-ridden state and dysphagia (P<0.05), and tended to appear later than the early symptoms. These results would reflect the early natural course of childhood and adolescent ALD before treatment, and provide a basis for the evaluation of therapeutic trials for ALD.
2001

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Citation

Suzuki Y; Imamura A; Shimozawa N; Kondo N, “The clinical course of childhood and adolescent adrenoleukodystrophy before and after Lorenzo's oil,” Pediatric Palliative Care Library, accessed May 27, 2024, https://pedpalascnetlibrary.omeka.net/items/show/12221.