Beta-endorphin concentrations in the peripheral blood mononuclear cells of migraine and tension-type headache patients

Title

Beta-endorphin concentrations in the peripheral blood mononuclear cells of migraine and tension-type headache patients

Creator

Leone M; Sacerdote P; D'Amico D; Panerai AE; Bussone G

Publisher

Cephalalgia

Date

1992

Subject

Female; Humans; Male; Adult; Middle Aged; beta-Endorphin/blood; Biomarkers of Pain; Radioimmunoassay; Leukocytes; Headache/blood; Migraine Disorders/blood; Mononuclear/chemistry

Description

Levels of beta-endorphin in peripheral blood mononuclear cells have been studied as a new approach to investigating opioid tone in migraine and tension-type headache. Sixty-one patients with migraine without aura, 39 with migraine with aura and 23 with episodic tension-type headache were compared with 37 healthy controls. Peripheral blood samples were taken from patients not enduring headache attacks and not undergoing prophylactic treatment. A significant reduction in peripheral blood mononuclear cell beta-endorphin concentrations was observed in migraine patients with and without aura, but not in tension-type headache patients. Altered transmitter modulation to peripheral blood mononuclear cells may be the cause of this alteration, which could be part of a more diffuse opioid system derangement in migraine subjects.
1992

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

154-157

Issue

3

Volume

12

Citation

Leone M; Sacerdote P; D'Amico D; Panerai AE; Bussone G, “Beta-endorphin concentrations in the peripheral blood mononuclear cells of migraine and tension-type headache patients,” Pediatric Palliative Care Library, accessed October 19, 2021, https://pedpalascnetlibrary.omeka.net/items/show/12134.

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