Beta-endorphin levels are reduced in peripheral blood mononuclear cells of cluster headache patients
Title
Beta-endorphin levels are reduced in peripheral blood mononuclear cells of cluster headache patients
Creator
Leone M; Sacerdote P; D'Amico D; Panerai AE; Bussone G
Identifier
Publisher
Cephalalgia
Date
1993
Subject
Female; Humans; Male; Adult; Reference Values; beta-Endorphin/blood; Cluster Headache/blood; Monocytes/metabolism
Description
Opioid system hypofunction has been postulated in cluster headache (CH) on the basis of reduced opioid levels found in the cerebrospinal fluid (CSF). In this study beta-endorphin levels were monitored in the peripheral blood mononuclear cells of 65 episodic CH patients (32 in remission and 33 in cluster period) and 50 healthy controls. Beta-endorphin levels were significantly lower than controls in CH patients experiencing both phases of the illness (ANOVA, p < 0.0001). The persistence of this abnormality during pain-free remission suggests a primary alteration in the regulation of beta-endorphin in peripheral blood mononuclear cells. We speculate that these findings reflect reduced CNS levels of beta-endorphin in CH.
1993
Rights
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
Journal Article
Citation List Month
Backlog
Citation
Leone M; Sacerdote P; D'Amico D; Panerai AE; Bussone G, “Beta-endorphin levels are reduced in peripheral blood mononuclear cells of cluster headache patients,” Pediatric Palliative Care Library, accessed April 19, 2024, https://pedpalascnetlibrary.omeka.net/items/show/12133.