Beta-endorphin levels are reduced in peripheral blood mononuclear cells of cluster headache patients

Title

Beta-endorphin levels are reduced in peripheral blood mononuclear cells of cluster headache patients

Creator

Leone M; Sacerdote P; D'Amico D; Panerai AE; Bussone G

Publisher

Cephalalgia

Date

1993

Subject

Female; Humans; Male; Adult; Reference Values; beta-Endorphin/blood; Cluster Headache/blood; Monocytes/metabolism

Description

Opioid system hypofunction has been postulated in cluster headache (CH) on the basis of reduced opioid levels found in the cerebrospinal fluid (CSF). In this study beta-endorphin levels were monitored in the peripheral blood mononuclear cells of 65 episodic CH patients (32 in remission and 33 in cluster period) and 50 healthy controls. Beta-endorphin levels were significantly lower than controls in CH patients experiencing both phases of the illness (ANOVA, p < 0.0001). The persistence of this abnormality during pain-free remission suggests a primary alteration in the regulation of beta-endorphin in peripheral blood mononuclear cells. We speculate that these findings reflect reduced CNS levels of beta-endorphin in CH.
1993

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

413-416

Issue

6

Volume

13

Citation

Leone M; Sacerdote P; D'Amico D; Panerai AE; Bussone G, “Beta-endorphin levels are reduced in peripheral blood mononuclear cells of cluster headache patients,” Pediatric Palliative Care Library, accessed October 25, 2021, https://pedpalascnetlibrary.omeka.net/items/show/12133.

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