Ventilatory effects of morphine, pethidine and methadone in children
Title
Ventilatory effects of morphine, pethidine and methadone in children
Creator
Hamunen K
Identifier
Publisher
British Journal Of Anaesthesia
Date
1993
Subject
Child; Female; Humans; Male; Pain; Time Factors; Depression; Preschool; Non-U.S. Gov't; Research Support; Oxygen/blood; Postoperative/prevention & control; Respiration/drug effects; Chemical; Meperidine/pharmacology; Methadone/pharmacology; Morphine/pharmacology; Tidal Volume/drug effects
Description
The ventilatory effects of single i.v. doses of morphine 0.1 mg kg-1, pethidine 0.67 mg kg-1 and methadone 0.1 mg kg-1 were compared after ophthalmic surgery in an open, randomized study in 30 children aged 3-8 yr. Ventilatory changes after each drug had distinctive profiles, with appreciable individual variation. Acutely, the decrease in ventilatory frequency was greater with pethidine and methadone than with morphine. The acute decrease in oxygen saturation was greater with methadone and pethidine than with morphine. Methadone produced a greater and longer lasting increase in end-tidal carbon dioxide and greater decrease in end-tidal oxygen than morphine or pethidine. Changes in end-tidal carbon dioxide and oxygen concentrations and saturation were most transient after pethidine and of longest duration after methadone. No child developed apnoea or hypoventilation requiring assistance.
1993
Rights
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Hamunen K, “Ventilatory effects of morphine, pethidine and methadone in children,” Pediatric Palliative Care Library, accessed February 6, 2025, https://pedpalascnetlibrary.omeka.net/items/show/12048.