Patient-controlled analgesia with low dose background infusions after lower abdominal surgery in children

Title

Patient-controlled analgesia with low dose background infusions after lower abdominal surgery in children

Creator

Doyle E; Harper I; Morton NS

Publisher

British Journal Of Anaesthesia

Date

1993

Subject

Child; Female; Humans; Male; Pain; Analgesia; Drug Administration Schedule; Non-U.S. Gov't; Research Support; Comparative Study; Infusions; Intravenous; Nausea/chemically induced; Morphine/administration & dosage/adverse effects; Postoperative Period; Sleep/drug effects; Vomiting/chemically induced; Postoperative/drug therapy; Appendectomy; Patient-Controlled/adverse effects/methods

Description

Forty-five children (aged 6-12 yr) undergoing appendicectomy received one of three analgesic regimens using patient-controlled analgesia (PCA) with morphine: no background infusion (BO); background infusion 4 micrograms kg-1 h-1 (B4); background infusion 10 micrograms kg-1 h-1 (B10). Total consumption of morphine was greater in group B10 compared with groups B0 (P < 0.01) and B4 (P < 0.05). There was no significant difference in morphine consumption in groups B0 and B4. All three groups self-administered similar amounts of morphine and there were no significant differences in pain scores or incidence of excessive sedation. Group B4 suffered less hypoxaemia compared with groups B0 (P < 0.01) and B10 (P < 0.001). Group B10 suffered more nausea and vomiting than groups B0 (P < 0.001) and B4 (P < 0.001), but there was no significant difference in the incidence of nausea and vomiting between groups B0 and B4. Groups B4 and B10 spent more time at night asleep than group B0 (P < 0.05). There were no significant differences between the groups in the amount of time spent asleep during the day. Inclusion of a background infusion of morphine 4 micrograms kg-1 h-1 in a PCA regimen for children did not increase the incidence of side effects and was associated with less hypoxaemia and a better sleep pattern than no background infusion.
1993

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

818-822

Issue

6

Volume

71

Citation

Doyle E; Harper I; Morton NS, “Patient-controlled analgesia with low dose background infusions after lower abdominal surgery in children,” Pediatric Palliative Care Library, accessed October 26, 2021, https://pedpalascnetlibrary.omeka.net/items/show/12047.

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