Physiological changes, plasma beta-endorphin and cortisol responses to tracheal intubation in neonates

Title

Physiological changes, plasma beta-endorphin and cortisol responses to tracheal intubation in neonates

Creator

Pokela ML; Koivisto M

Publisher

Acta Paediatrica

Date

1994

Subject

Humans; infant; Drug Therapy; Analgesia; Blood Pressure; Heart Rate; beta-Endorphin/blood; Biomarkers of Pain; Newborn; Blood Glucose/metabolism; Oxygen/blood; Intubation; Hydrocortisone/blood; Combination; Alfentanil; Glycopyrrolate/therapeutic use; Intratracheal/adverse effects; Meperidine; Premedication; Succinylcholine

Description

Physiological, plasma beta-endorphin and cortisol responses to nasotracheal intubation were studied in 20 distressed infants of median age 0.3 days (range 0.1-23 days) randomized into groups given pethidine 1 mg/kg (n = 10) or alfentanil 20 micrograms/kg plus suxamethonium 1.5 mg/kg (n = 10) before intubation. All of the infants were given glycopyrrolate 3-5 micrograms/kg. Hypoxaemia during intubation was found in all 10 infants in the pethidine group and in 7 of 10 infants in the alfentanil-suxamethonium group, its duration being significantly longer in the pethidine group and being associated with the duration of the intubation procedure. Blood pressure increased, but not statistically significantly, in all except 2 patients in the alfentanil-suxamethonium group and bradycardia appeared in 1 patient in each group. Plasma beta-endorphin and cortisol values did not show any statistically significant intra-group or inter-group differences. Newborn infants suffer from hypoxaemia during intubation when awake more and therefore need adequate premedication before elective intubation. One alternative is the combination of glycopyrrolate, alfentanil and suxamethonium described here, although the ideal medication and dosage still remain to be defined.
1994

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

151-156

Issue

2

Volume

83

Citation

Pokela ML; Koivisto M, “Physiological changes, plasma beta-endorphin and cortisol responses to tracheal intubation in neonates,” Pediatric Palliative Care Library, accessed December 3, 2021, https://pedpalascnetlibrary.omeka.net/items/show/11920.

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