Genetic classification of primary neurodegenerative disease

Title

Genetic classification of primary neurodegenerative disease

Creator

Hardy J; Gwinn-Hardy K

Publisher

Science

Date

1998

Subject

Humans; Mutation; Brain; Neurodegenerative Diseases; Genes; Trinucleotide Repeats; Parkinson Disease; Alzheimer Disease; Dominant; Nerve Tissue Proteins; Peptides; Synucleins; tau Proteins

Description

Review During the past 10 years (the "decade of the brain"), some of the genetic causes of many of the primary neurodegenerative diseases, which include Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, prion disease, and many ataxic syndromes, have been found. These breakthroughs mean that for many of these diseases we now know the initiating trigger as well as the final outcome. These diseases have many pathological mechanisms in common, and there may be relatively few pathways to neuronal death seen in these disorders. Thus, treatment strategies developed for a particular disease may be found to have efficacy in more than one disorder.
1998-11

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

1075-1079

Issue

5391

Volume

282

Citation

Hardy J; Gwinn-Hardy K, “Genetic classification of primary neurodegenerative disease,” Pediatric Palliative Care Library, accessed October 24, 2021, https://pedpalascnetlibrary.omeka.net/items/show/11909.

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