Decreased levels of beta-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction

Decreased levels of beta-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction

Buratti T; Schratzberger P; Dunzendorfer S; Manfreda SE; Pechlaner C; Joannidis M; Sacerdote P; Panerai AE; Wiedermann CJ

Cardiology

1998

Female; Humans; Male; Middle Aged; Biomarkers of Pain; Biomarkers Reference List; Leukocytes; beta-Endorphin/blood/immunology; Myocardial Infarction/blood; C-Reactive Protein/analysis; Mononuclear/metabolism

Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive beta-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction. The concentrations of beta-endorphin in mononuclear leukocytes of 30.2 +/- 6.9 pg/10(6) cells on admission were in the normal range of 20-40 pg/10(6) cells and decreased significantly to 6.9 +/- 1.9 pg/10(6) cells after 48 h (p < 0.05). Decreased levels of mononuclear leukocyte-associated beta-endorphin in acute myocardial infarction may be due to the release of endogenous opioid after stimulation by stress and acute-phase reactants and play a role in inflammation and pain.

1998

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