Decreased levels of beta-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction

Title

Decreased levels of beta-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction

Creator

Buratti T; Schratzberger P; Dunzendorfer S; Manfreda SE; Pechlaner C; Joannidis M; Sacerdote P; Panerai AE; Wiedermann CJ

Identifier

Publisher

Cardiology

Date

1998

Subject

Female; Humans; Male; Middle Aged; Biomarkers of Pain; Biomarkers Reference List; Leukocytes; beta-Endorphin/blood/immunology; Myocardial Infarction/blood; C-Reactive Protein/analysis; Mononuclear/metabolism

Description

Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive beta-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction. The concentrations of beta-endorphin in mononuclear leukocytes of 30.2 +/- 6.9 pg/10(6) cells on admission were in the normal range of 20-40 pg/10(6) cells and decreased significantly to 6.9 +/- 1.9 pg/10(6) cells after 48 h (p < 0.05). Decreased levels of mononuclear leukocyte-associated beta-endorphin in acute myocardial infarction may be due to the release of endogenous opioid after stimulation by stress and acute-phase reactants and play a role in inflammation and pain.
1998

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

43-47

Issue

1

Volume

90

Citation

Buratti T; Schratzberger P; Dunzendorfer S; Manfreda SE; Pechlaner C; Joannidis M; Sacerdote P; Panerai AE; Wiedermann CJ, “Decreased levels of beta-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction,” Pediatric Palliative Care Library, accessed August 5, 2021, https://pedpalascnetlibrary.omeka.net/items/show/11883.

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