Sleep-disordered breathing and respiratory failure in acid maltase deficiency
Title
Sleep-disordered breathing and respiratory failure in acid maltase deficiency
Creator
Mellies U; Ragette R; Schwake C; et al
Identifier
Publisher
Neurology
Date
2001
Subject
Child; Humans; Adult; Middle Aged; Sensitivity and Specificity; Predictive Value of Tests; adolescent; Preschool; Q3 Literature Search; REM; Sleep; Polysomnography; Diaphragm/physiopathology; Glycogen Storage Disease Type II/complications; Respiratory Insufficiency/diagnosis/etiology/physiopathology; Sleep Apnea Syndromes/diagnosis/etiology/physiopathology; Vital Capacity
Description
BACKGROUND: Sleep-disordered breathing (SDB) and respiratory failure (RF) are complications of acid maltase deficiency (AMD), a rare hereditary myopathy. OBJECTIVE: To define the relationship between lung and respiratory muscle function, to establish incidence and patterns of SDB, and to determine daytime predictors of SDB. METHODS: Sitting and supine lung and respiratory muscle function tests were obtained in 27 subjects with juvenile and adult AMD (aged 39 +/- 19 years) and compared with outcomes of polysomnography. RESULTS: Ventilatory restriction was present in 17/27 subjects. Inspiratory vital capacity (IVC) correlated (p 50 mm Hg) first in REM sleep, then in non-REM sleep (p < 0.005). SDB was predicted by DW (sensitivity 80%, specificity 86%) and nocturnal hypoventilation by IVC < 40% (sensitivity 80%, specificity 93%). Noninvasive ventilation, instituted for daytime respiratory failure or nocturnal hypoventilation, normalized daytime and nocturnal gas exchange (p < 0.005). CONCLUSION: Vital capacity correlates with respiratory muscle function in AMD. Diaphragm weakness is the major cause of SDB and RF. SDB and nocturnal hypoventilation are predictable from daytime function tests.
2001
Rights
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Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Mellies U; Ragette R; Schwake C; et al, “Sleep-disordered breathing and respiratory failure in acid maltase deficiency,” Pediatric Palliative Care Library, accessed March 29, 2024, https://pedpalascnetlibrary.omeka.net/items/show/11797.