Efficacy of psychotropic drugs for reducing self-injurious behavior in the developmental disabilities

Efficacy of psychotropic drugs for reducing self-injurious behavior in the developmental disabilities

Aman MG

Annals Of Clinical Psychiatry : Official Journal Of The American Academy Of Clinical Psychiatrists

1993

Female; Male; P.H.S.; U.S. Gov't; Comparative Study; Receptors; Human; Treatment Outcome; Support; Antipsychotic Agents/pd [Pharmacology]; Mental Retardation/di [Diagnosis]; Antipsychotic Agents/ad [Administration & Dosage]; Antipsychotic Agents/tu [Therapeutic Use]; Mental Retardation/co [Complications]; Self-Injurious Behavior/dt [Drug Therapy]; Adrenergic beta-Antagonists/tu [Therapeutic Use]; Anti-Anxiety Agents/tu [Therapeutic Use]; Antidepressive Agents/cl [Classification]; Antidepressive Agents/tu [Therapeutic Use]; Dopamine/me [Metabolism]; Lithium Carbonate/tu [Therapeutic Use]; Naloxone/tu [Therapeutic Use]; Naltrexone/tu [Therapeutic Use]; Self-Injurious Behavior/co [Complications]

Self-injurious behavior (SIB) is a serious and moderately prevalent problem behavior among developmentally disabled persons, and it frequently leads to treatment with psychotropic medication. The empirical literature relating to the efficacy of pharmacological intervention is comprehensively reviewed. The rationales for using some "newer" agents, such as serotonin reuptake blockers, opiate blockers, and beta-adrenergic blockers are described. In general there are insufficient data to draw conclusions about specific agents. Evidence for a possible role in managing SIB is strongest for thioridazine, lithium carbonate, and the opiate antagonists. However, further research is needed to define the specific indications, if any, for each of these. Impediments to past research are discussed, possible refinements are offered for future research, and recommendations for treatment are offered. [References: 117]

1993

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