Comparison of morphine and methadone for prevention of postoperative pain in 3- to 7-year-old children
Title
Comparison of morphine and methadone for prevention of postoperative pain in 3- to 7-year-old children
Creator
Berde CB; Beyer JE; Bournaki MC; Levin CR; Sethna NF
Publisher
Journal Of Pediatrics
Date
1991
Subject
Child; Female; Male; Pain; Pain Measurement; Prospective Studies; Analysis of Variance; Double-Blind Method; Preschool; Non-U.S. Gov't; Comparative Study; Drug Evaluation; Human; Support; Postoperative/prevention & control; algorithms; Intraoperative Care; Methadone/adverse effects/pharmacokinetics/therapeutic use; Morphine/adverse effects/therapeutic use
Description
A randomized, double-blind, prospective study was performed to determine the effects of perioperative administration of morphine or methadone on postoperative analgesic requirements and pain scores in 35 children aged 3 to 7 years undergoing major surgery. After a standardized induction of anesthesia, methadone or morphine, 0.2 mg/kg, was blindly administered, and supplemental doses were titrated to achieve comfort in the recovery room. Pain was assessed during the next 36 hours with a combination of validated behavioral and self-report measures. Patients in the methadone group required fewer supplemental opioid analgesic drugs during the next 36 hours, and reported lower pain scores. No patient had prolonged emergence from anesthesia, and no patient required naloxone or postoperative ventilatory assistance. No major adverse events occurred. We conclude that perioperative intravenous administration of methadone is an effective, inexpensive, and technologically simple means for providing prolonged analgesia for children after surgery.
1991
Rights
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
Journal Article
Citation List Month
Backlog
Citation
Berde CB; Beyer JE; Bournaki MC; Levin CR; Sethna NF, “Comparison of morphine and methadone for prevention of postoperative pain in 3- to 7-year-old children,” Pediatric Palliative Care Library, accessed February 16, 2025, https://pedpalascnetlibrary.omeka.net/items/show/11640.