Influence of early phase clinical trial enrollment on patterns of end-of-life care for children with advanced cancer

Title

Influence of early phase clinical trial enrollment on patterns of end-of-life care for children with advanced cancer

Creator

Ananth P; Monsereenusorn C; Ma C; Al-Sayegh H; Wolfe J; Rodriguez-Galindo C

Identifier

Publisher

Pediatric Blood And Cancer

Date

2017

Subject

Advanced Cancer; Female; Male; Terminal Care; Child; Childhood Cancer; Clinical Trial; Cohort Analysis; Controlled Study; Death; Health Care Utilization; Human; Major Clinical Study; Palliative Therapy

Description

We conducted a retrospective cohort study of 125 pediatric oncology patients who died in 2010-2014 to explore how healthcare utilization, pediatric palliative care (PPC) receipt, and end-of-life care (EOLC) differed between patients enrolled in early phase clinical trials (EP) and those not enrolled (NEP). Baseline characteristics and healthcare utilization did not significantly differ between groups. EP patients received PPC consultation closer to death than NEP patients (median days before death = 58 [interquartile range = 16-84] vs. 85 [32-173]; P = 0.04). Our findings suggest that early phase trial enrollment does not substantially alter EOLC for children with advanced cancer but may contribute to later PPC engagement. Future studies should definitively assess the relationship between trial enrollment and PPC timing.

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Citation List Month

Oncology 2017 List

Collection

Citation

Ananth P; Monsereenusorn C; Ma C; Al-Sayegh H; Wolfe J; Rodriguez-Galindo C, “Influence of early phase clinical trial enrollment on patterns of end-of-life care for children with advanced cancer,” Pediatric Palliative Care Library, accessed February 3, 2023, https://pedpalascnetlibrary.omeka.net/items/show/11166.

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