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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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2020 Developing World List
Text
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Citation List Month
Developing World 2020 List
URL Address
<a href="http://doi.org/10.1200/go.20.00159" target="_blank" rel="noreferrer noopener">http://doi.org/10.1200/go.20.00159</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives
Publisher
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JCO Global Oncology
Date
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2020
Subject
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pediatrics; cancer; oncology; Africa; clinical trials; collaborative research
Creator
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van Heerden J; Zaghloul M; Neven A; de Rojas T; Geel J; Patte C; Balagadde-Kambugu J; Hesseling P; Tchintseme F; Bouffet E; Hessissen L
Description
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PURPOSE: Adequate clinical services have yet to be established in the majority of African countries, where childhood cancer survival rates vary from 8.1% to 30.3%. The aim of this review is to describe the landscape of pediatric oncology trials in Africa, identify challenges, and offer future opportunities for research collaborations. METHOD(S): The study includes data from the International Pediatric Oncology Society (SIOP) global mapping survey, meta-research identifying trials in Africa in ClinicalTrials.gov, and a literature overview of publications on the subject of pediatric oncology clinical research supported by expert opinions on the current situation and challenges. RESULT(S): The SIOP global mapping survey received responses from 47 of 54 African countries, of which 23 have active clinical research programs. A preliminary search of ClinicalTrials.gov showed that only 105 (12.1%) of 868 African oncology studies included children and adolescents. Of these, 53 (50.5%) were interventional trials according to the registry's classification. The small number of African trials for children and adolescents included palliative care and leukemia trials. In African oncology journals and international pediatric oncology journals, < 1% of the pediatric oncology publications come from Africa. Services and research were strengthened by international collaboration. National studies focused on clinical needs, local challenges, or interventional priorities. Both the literature review and the expert opinions highlight the need to expand clinical research in Africa, despite ongoing regional instability and lack of resources. CONCLUSION(S): While a low number of pediatric clinical treatment trials are open to African children and adolescents, clinical research of high quality is being done in Africa. Several initiatives are stimulating the development of the research capacity across the continent, which should increase the publication output.
Identifier
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<a href="http://doi.org/10.1200/go.20.00159" target="_blank" rel="noreferrer noopener">10.1200/go.20.00159</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2020
Africa
Balagadde-Kambugu J
Bouffet E
Cancer
Clinical Trials
collaborative research
de Rojas T
Developing World 2020 List
Geel J
Hesseling P
Hessissen L
JCO Global Oncology
Neven A
Oncology
Patte C
Pediatrics
Tchintseme F
van Heerden J
Zaghloul M