1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12660386" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12660386</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oral opioid therapy for chronic peripheral and central neuropathic pain
Publisher
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New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Female; Male; Adult; Analgesics; Aged; Outcome Assessment (Health Care); Double-Blind Method; 80 and over; Non-U.S. Gov't; P.H.S.; U.S. Gov't; Chronic disease; Dose-Response Relationship; Drug; Drug Tolerance; Human; Support; Middle Age; Opioid/administration & dosage/adverse effects/therapeutic; use; Central Nervous System Diseases/drug therapy; Levorphanol/administration & dosage/adverse effects/therapeutic use; Neuralgia/drug therapy; Peripheral Nervous System Diseases/drug therapy
Creator
An entity primarily responsible for making the resource
Rowbotham MC; Twilling L; Davies PS; Reisner L; Taylor K; Mohr D
Description
An account of the resource
BACKGROUND: Although opioids are commonly used to treat chronic neuropathic pain, there are limited data to guide their use. Few controlled trials have been performed, and many types of neuropathic pain remain unstudied. METHODS: Adults with neuropathic pain that was refractory to treatment were randomly assigned to receive either high-strength (0.75-mg) or low-strength (0.15-mg) capsules of the potent mu-opioid agonist levorphanol for eight weeks under double-blind conditions. Intake was titrated by the patient to a maximum of 21 capsules of either strength per day. Outcome measures included the intensity of pain as recorded in a diary, the degree of pain relief, quality of life, psychological and cognitive function, the number of capsules taken daily, and blood levorphanol levels. RESULTS: Among the 81 patients exposed to the study drug, high-strength levorphanol capsules reduced pain by 36 percent, as compared with a 21 percent reduction in pain in the low-strength group (P=0.02). On average, patients in the high-strength group took 11.9 capsules per day (8.9 mg per day) and patients in the low-strength group took close to the 21 allowed (18.3 capsules per day; 2.7 mg per day). Affective distress and interference with functioning were reduced, and sleep was improved, but there were no differences between the high-strength group and the low-strength group in terms of these variables. Noncompletion of the study was primarily due to side effects of the opioid. Patients with central pain after stroke were the least likely to report benefit. CONCLUSIONS: The reduction in the intensity of neuropathic pain was significantly greater during treatment with higher doses of opioids than with lower doses. Higher doses produced more side effects without significant additional benefit in terms of other outcome measures.
2003
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
80 And Over
Adult
Aged
Analgesics
Backlog
Central Nervous System Diseases/drug therapy
Chronic Disease
Davies PS
Dose-Response Relationship
Double-Blind Method
Drug
Drug Tolerance
Female
Human
Journal Article
Levorphanol/administration & dosage/adverse effects/therapeutic use
Male
Middle Age
Mohr D
Neuralgia/drug therapy
New England Journal Of Medicine
Non-U.S. Gov't
Opioid/administration & dosage/adverse effects/therapeutic
Outcome Assessment (health Care)
P.H.S.
Peripheral Nervous System Diseases/drug therapy
Reisner L
Rowbotham MC
Support
Taylor K
Twilling L
U.S. Gov't
use
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
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URL Address
<a href="http://doi.org/10.1016/0952-8180(95)00201-4" target="_blank" rel="noreferrer">http://doi.org/10.1016/0952-8180(95)00201-4</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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High-dose oral morphine in cancer pain management: a report of twelve cases
Publisher
An entity responsible for making the resource available
Journal of Clinical Anesthesia
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
Subject
The topic of the resource
Female; Male; Pain; Analgesics; Aged; Fatal Outcome; Non-U.S. Gov't; Human; Case Report; Support; Intractable/drug therapy/etiology; Middle Age; Morphine/administration & dosage/adverse effects/therapeutic use; Neoplasms/complications; Opioid/administration & dosage/adverse effects/therapeutic; use
Creator
An entity primarily responsible for making the resource
Radbruch L; Grond S; Zech DJ; Bischoff A
Description
An account of the resource
We present 12 case reports from patients treated with more than 600 mg of morphine per day. We found no "opioid-nonresponsive pain" under treatment with a combination of morphine and nonopioids, supplemented with coanalgesics where appropriate. Side effects of morphine therapy were controlled with adjuvant drugs. Serious adverse effects were not observed. Episodes of break-through pain, dysphagia, and dyspnea caused by far advanced cancer disease were seen frequently.
1996
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0952-8180(95)00201-4" target="_blank" rel="noreferrer">10.1016/0952-8180(95)00201-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1996
Aged
Analgesics
Backlog
Bischoff A
Case Report
Fatal Outcome
Female
Grond S
Human
Intractable/drug therapy/etiology
Journal Article
Journal of Clinical Anesthesia
Male
Middle Age
Morphine/administration & dosage/adverse effects/therapeutic use
Neoplasms/complications
Non-U.S. Gov't
Opioid/administration & dosage/adverse effects/therapeutic
Pain
Radbruch L
Support
use
Zech DJ