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Text
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<a href="http://doi.org/10.1111/j.1365-2125.2005.02422.x" target="_blank" rel="noreferrer">http://doi.org/10.1111/j.1365-2125.2005.02422.x</a>
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Title
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Should domperidone be used for the treatment of gastro-oesophageal reflux in children? Systematic review of randomized controlled trials in children aged 1 month to 11 years old
Publisher
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British Journal of Clinical Pharmacology
Date
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2005
Subject
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PedPal Lit; 'improved' or 'unchanged'. The secondary pH-metric outcome of the number of reflux episodes; a good or excellent result was obtained in 93% of the domperidone group compared with 33% of the controls (P < 0.05). In the trial undertaken by de Loore; after 2 weeks of treatment 75% of patients treated with domperidone were found not to be vomiting; and reference citations of the RCTs that had been found electronically. RESULTS: Four RCTs were identified. Only the two older trials showed any benefits of domperidone on clinical symptoms of GORD in older children; Antiemetics/therapeutic use Child Child; compared with 43% in the metoclopramide group and 7% in the placebo group. The trial by Corraccio gave no detailed results regarding the primary outcomes of effect of domperidone on symptoms but simply reported 'cured'; drug therapy Humans Infant Randomized Controlled Trials/methods Research Design Treatment Outcome; Medline (Pub-med) 1966 to present and Embase from 1974 to 2004; Preschool Domperidone/; the widespread use of unlicensed medicines for GOR is not warranted.; therapeutic use Dopamine Antagonists/; therapeutic use Evidence-Based Medicine Gastroesophageal Reflux/; there was no robust evidence of efficacy for the treatment of GOR with domperidone in young children. Given the usually benign nature of the condition; was reduced with domperidone. CONCLUSION: From the limited evidence available; which were the primary outcome measures. In the trial undertaken by Clara
Creator
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Pritchard DS; Baber N; Stephenson T
Identifier
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<a href="http://doi.org/10.1111/j.1365-2125.2005.02422.x" target="_blank" rel="noreferrer">10.1111/j.1365-2125.2005.02422.x</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
Description
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2005
2005
a good or excellent result was obtained in 93% of the domperidone group compared with 33% of the controls (P < 0.05). In the trial undertaken by de Loore
after 2 weeks of treatment 75% of patients treated with domperidone were found not to be vomiting
and reference citations of the RCTs that had been found electronically. RESULTS: Four RCTs were identified. Only the two older trials showed any benefits of domperidone on clinical symptoms of GORD in older children
Antiemetics/therapeutic use Child Child
Baber N
Backlog
British Journal of Clinical Pharmacology
compared with 43% in the metoclopramide group and 7% in the placebo group. The trial by Corraccio gave no detailed results regarding the primary outcomes of effect of domperidone on symptoms but simply reported 'cured'
drug therapy Humans Infant Randomized Controlled Trials/methods Research Design Treatment Outcome
Journal Article
Medline (Pub-med) 1966 to present and Embase from 1974 to 2004
PedPal Lit
Preschool Domperidone/
Pritchard DS
Stephenson T
the widespread use of unlicensed medicines for GOR is not warranted.
therapeutic use Dopamine Antagonists/
therapeutic use Evidence-Based Medicine Gastroesophageal Reflux/
there was no robust evidence of efficacy for the treatment of GOR with domperidone in young children. Given the usually benign nature of the condition
was reduced with domperidone. CONCLUSION: From the limited evidence available
which were the primary outcome measures. In the trial undertaken by Clara