1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1111/j.1365-2125.2005.02445.x" target="_blank" rel="noreferrer">http://doi.org/10.1111/j.1365-2125.2005.02445.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
How children's responses to drugs differ from adults
Publisher
An entity responsible for making the resource available
British Journal of Clinical Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
PedPal Lit; a drug - a truly age-dependent difference in pharmacodynamics. This may be true of both the desired action and adverse events. Examples are given. Programming by drugs is also a phenomenon almost exclusive to early life; Adult Aging/metabolism Bayes Theorem Child Clinical Trials/methods Humans PharmacogeneticsPharmacokinetics Research Design%X Children are not small adults. However; and response to; different 'host' response and different adverse drug reactions can all explain why some drugs behave differently in children. However; different disease variants; different pharmacodynamics; example s are discussed. Different pathophysiology; i.e. permanent effects result from a stimulus applied at a sensitive point in development ('critical window'); often in fetal or neonatal life. Again; stage of development can alter the action of; the main thesis of this review will be that children's responses to drugs have much in common with the responses in adults and indeed in other mammals. Often; we need to explore ways to avoid re-inventing the wheel by determining how data from adult animal and human models can help inform research and practice for children.
Creator
An entity primarily responsible for making the resource
Stephenson T
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1365-2125.2005.02445.x" target="_blank" rel="noreferrer">10.1111/j.1365-2125.2005.02445.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2005
2005
a drug - a truly age-dependent difference in pharmacodynamics. This may be true of both the desired action and adverse events. Examples are given. Programming by drugs is also a phenomenon almost exclusive to early life
Adult Aging/metabolism Bayes Theorem Child Clinical Trials/methods Humans PharmacogeneticsPharmacokinetics Research Design%X Children are not small adults. However
and response to
Backlog
British Journal of Clinical Pharmacology
different 'host' response and different adverse drug reactions can all explain why some drugs behave differently in children. However
different disease variants
different pharmacodynamics
example s are discussed. Different pathophysiology
i.e. permanent effects result from a stimulus applied at a sensitive point in development ('critical window')
Journal Article
often in fetal or neonatal life. Again
PedPal Lit
stage of development can alter the action of
Stephenson T
the main thesis of this review will be that children's responses to drugs have much in common with the responses in adults and indeed in other mammals. Often
we need to explore ways to avoid re-inventing the wheel by determining how data from adult animal and human models can help inform research and practice for children.