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Dublin Core
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Title
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Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
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URL Address
<a href="http://doi.org/10.1097/PEP.0b013e3182351f04" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/PEP.0b013e3182351f04</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Validation of the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND)
Publisher
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Pediatric Physical Therapy
Date
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2011
Subject
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infant; Pediatrics; Rehabilitation; validity; outcome assessment; child; female; male; disease severity; (health care); atrophies of childhood/diagnosis; child development/physiology; childhood/physiopathology; disability evaluation; humans; motor skills/physiology; natural-history; physical therapy/methods; preschool; psychometrics/methods; severity of illness index; sma; smn2 copy number; spinal muscular; spinal muscular atrophies of; spinal muscular-atrophy; tone and motor problems; SMA1; tool development; scale development; CHOP INTEND
Creator
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Glanzman A M; McDermott M P; Montes J; Martens W B; Flickinger J; Riley S; Quigley J; Dunaway S; O'Hagen J; Deng L Y; Chung W K; Tawil R; Darras B T; Yang M; Sproule D; De Vivo D C; Kaufmann P; Finkel R S; Pediatric Neuromuscular Clinical Research; Muscle Study Group
Description
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Purpose: Preliminary validation of the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND) for motor skill assessment in spinal muscular atrophy type I. Methods: A total of 27 subjects 3 to 260 months old (mean = 49, SD = 69) with spinal muscular atrophy-I were evaluated with the CHOP INTEND. Subjects were evaluated as part of a multicenter natural history study. Results: CHOP INTEND scores and age were significantly correlated (r = -0.51, P = .007; 2 survival of the motor neuron [SMN] 2 gene copies, n = 16, r = -0.60, 3 SMN2 gene copies, n = 9, r = -0.83). Respiratory support and CHOP INTEND scores were correlated (r = -0.74, P <.0001, n = 26). The CHOP INTEND and age regression in patients with 2 copies versus 3 copies of SMN2 approached significance (P = .0711, n = 25). Subjects who required respiratory support scored significantly lower (mean = 15.5, SD = 10.2 vs mean = 31.2, SD = 4.2, P <.0001, n = 27). Correlation with motor unit number estimation and combined motor unit activation were not significant. Conclusion: The CHOP INTEND reflects measures of disease severity and supports continued exploration of the CHOP INTEND. (Pediatr Phys Ther 2011; 23: 322-326)
Identifier
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<a href="http://doi.org/10.1097/PEP.0b013e3182351f04" target="_blank" rel="noreferrer noopener">10.1097/PEP.0b013e3182351f04</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
(health care)
2011
atrophies of childhood/diagnosis
Child
Child Development/physiology
childhood/physiopathology
CHOP INTEND
Chung W K
Darras B T
De Vivo D C
Deng L Y
Disability Evaluation
Disease Severity
Dunaway S
Female
Finkel R S
Flickinger J
Glanzman A M
Humans
Infant
Kaufmann P
Male
Martens W B
McDermott M P
Montes J
Motor Skills/physiology
Muscle Study Group
natural-history
O'Hagen J
outcome assessment
Pediatric Neuromuscular Clinical Research
Pediatric Physical Therapy
Pediatrics
physical therapy/methods
Preschool
Psychometrics/methods
Quigley J
Rehabilitation
Riley S
scale development
Severity Of Illness Index
Sma
SMA1
smn2 copy number
spinal muscular
spinal muscular atrophies of
spinal muscular-atrophy
Sproule D
Tawil R
tone and motor problems
tool development
Validity
Yang M